"How many generations of IVF are there? Which one should I choose?" is one of the most common questions in consultations. The three generations are not simple sequential upgrades; they are tools suited to different indications.
I. First-Generation IVF (Conventional IVF)
The egg and sperm are placed in the same culture environment to fertilize naturally. It applies to most cases—such as tubal factors, ovulatory disorders, and unexplained infertility—and is the most basic and most commonly used approach.
II. Second-Generation IVF (ICSI)
A single sperm is injected directly into the egg under a microscope. It is mainly used for severe male factors (e.g., severe oligo-astheno-teratozoospermia) or previous fertilization failure. It addresses the step of "fertilization" and does not mean "better" or "more expensive means more suitable."
III. Third-Generation IVF (PGT)
Chromosomal or genetic testing of the embryo is performed before transfer. It is suitable for people with medical indications such as recurrent miscarriage, known monogenic genetic disorders, or advanced maternal age. The aim is to select a more suitable embryo, not to "customize" the sex.
IV. How to Choose: Look at Indications, Not Price
The specific path is determined by the physician based on a comprehensive assessment of both partners' tests, age, and medical history. For the applicability of ICSI and PGT, you may review the introductions on the ICSI service and PGT service pages.
Disclaimer: This article is for science popularization and information sharing only and does not constitute medical advice. IVF protocols, medications, and outcomes vary from person to person; the specific plan should be based on your attending physician's evaluation. For any assisted reproductive procedures, please comply with the laws and regulations of your location and of China.
